منابع مشابه
FAK and paxillin
FAK and paxillin are important components in integrin-regulated signaling. New evidence suggests that these two proteins function in crosstalk between cell-matrix and cell-cell adhesions. Further, new insight suggests that under some conditions these proteins inhibit cell migration, in contrast to their established roles in several cell systems as positive regulators of cell adhesion and migrat...
متن کاملDeconstructing FAK function
Polyglutamylation makes the cut L acroix et al. report that the addition of long glutamate side chains to tubulin stimulates microtubule disassembly by the microtubule-severing protein spastin. The C-terminal tails of tubulin subunits can be modifi ed in different ways, which might alter the recruitment of molecular motors and other microtubule-binding proteins. A family of glutamylase enzymes ...
متن کاملLKB1 represses focal adhesion kinase (FAK) signaling via a FAK-LKB1 complex to regulate FAK site maturation and directional persistence.
Liver kinase β1 (LKB1, also known as STK11) is a serine/threonine kinase that has multiple cellular functions including the regulation of cell polarity and motility. Murine proteomic studies show that LKB1 loss causes aberrant adhesion signaling; however, the mechanistic underpinnings of this relationship are unknown. We show that cells stably depleted of LKB1 or its co-activator STRADα have in...
متن کاملPyk 2 and Fak In
1. Abstract 2. Introduction 3. Discussion 3.1. Integrins and Osteoclasts 3.1.1. Mechanism of Osteoclastic Bone Resorption 3.1.2. Integrin alphavbeta3 is Involved in Regulating Osteoclastic Bone Resorption 3.2. PYK2 in Osteoclasts 3.2.1. Functional Expression of PYK2 in Osteoclasts 3.2.2. PYK2 in Integrin alphavbeta3-mediated Signaling in Osteoclasts 3.3. FAK in Osteoclasts 3.3.1. Functional Exp...
متن کاملFAK nuclear export signal sequences.
Ubiquitously expressed focal adhesion kinase (FAK), a critical component in transducing signals from sites of cell contacts with extracellular matrix, was named after its typical localization in focal adhesions. A nuclear localization of FAK has been also reported and its scaffolding role in nucleus and requirement for p53 ubiquitination were only recently described. Whereas FAK nuclear localiz...
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ژورنال
عنوان ژورنال: Cell Adhesion & Migration
سال: 2011
ISSN: 1933-6918,1933-6926
DOI: 10.4161/cam.5.1.13681